Round 1: Tossup 4

These proteins are the target of Emricasan, a compound once investigated as a treatment for nonalcoholic steato·hepatitis. Fluorescent probes linked to a Z-VAD (“ZEE-vad”) sequence label active forms of these proteins during a FLICA (“FLEE-kah”) assay. During infection, many cowpox viruses express C·r·m·A to inactivate these proteins, including one involved in the maturation of interleukins 18 and 1-beta. SMACs promote the activity of these proteins by antagonizing I·A·Ps. These proteins, some of which are recruited by the (*) CARD domain-containing APAF1, target (10[1])sequences that begin with an aspartic acid residue. “Executioner” kinds of these proteins cleave substrates such as actins and lamins to induce blebbing. For 10 points, name these proteases that operate in a cascading (10[1])fashion during apoptosis (10[1])■END■ (0[2])

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