Packet 1: Tossup 4

Fluorescent probes linked to a Z-VAD (“ZEE-vad”) sequence label active forms of these proteins during a FLICA (“FLEE-kah”) assay. During infection, many cowpox viruses express C·r·m·A to inactivate these proteins, including (15[1])one involved in the maturation of interleukins 18 and 1-beta. SMACs promote the activity (15[1])of these (15[1])proteins (15[1])by antagonizing I·A·Ps. In one pathway, one of these proteins numbered 8 converts Bid into tBid (15[1])following activation by FADD (15[1]-5[1])(“fad”). These proteins, (15[1])some (-5[1])of which are recruited by the (*) CARD (10[1])domain-containing APAF1, (10[2])target sequences (10[1])that begin with an aspartic (10[1])acid (10[1])residue. (-5[1])“Executioner” kinds of these proteins cleave (10[1])substrates such as actins and lamins (10[1])to induce blebbing. (10[1])For 10 points, (10[1])name these proteases (-5[1])that operate in a cascading fashion (10[1])during apoptosis (10[3])■END■ (10[5]0[8])

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Buzzes

Summary