Packet 1: Tossup 4

These proteins are the target of Emricasan, a compound once investigated as a treatment for nonalcoholic steato·hepatitis. Fluorescent probes linked to a Z-VAD (“ZEE-vad”) sequence label active forms of these proteins during a FLICA (“FLEE-kah”) assay. During infection, many cowpox viruses express C·r·m·A to inactivate these proteins, including one involved in the maturation of interleukins 18 and 1-beta. SMACs promote the activity of these proteins by antagonizing I·A·Ps. These proteins, some of which are recruited by the (*) CARD domain-containing APAF1, (10[1])target (10[1])sequences that begin with an aspartic (10[1])acid residue. “Executioner” kinds of these proteins cleave substrates such as actins and lamins to induce blebbing. For 10 points, name these proteases that operate in a cascading (10[1])fashion during apoptosis (10[1])■END■ (0[7])

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Summary