Round 1: Tossup 4

Fluorescent probes linked to a Z-VAD (“ZEE-vad”) sequence label active forms of these proteins during a FLICA (“FLEE-kah”) assay. During infection, many cowpox viruses express C·r·m·A to inactivate these proteins, including one involved in the maturation of interleukins 18 and 1-beta. SMACs promote the activity (15[1])of these proteins (15[1])by antagonizing I·A·Ps. In one pathway, one of these proteins numbered 8 converts Bid into tBid following activation by FADD (“fad”). These proteins, some of which are recruited by the (*) CARD domain-containing APAF1, (10[1])target sequences that begin with an aspartic acid residue. “Executioner” kinds of these proteins cleave substrates such as actins and lamins to induce blebbing. For 10 points, name these proteases that operate in a cascading fashion during apoptosis ■END■

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Summary