Round 1: Tossup 4

Fluorescent probes linked to a Z-VAD (“ZEE-vad”) sequence label active forms of these proteins during a FLICA (“FLEE-kah”) assay. During infection, many cowpox viruses express C·r·m·A to inactivate these proteins, including one involved in the maturation of interleukins 18 and 1-beta. SMACs promote the activity of these proteins by antagonizing I·A·Ps. In one pathway, one of these proteins numbered 8 converts Bid into tBid following activation by FADD (“fad”). These proteins, some of which are recruited by the (*) CARD domain-containing APAF1, target sequences that begin with an aspartic acid residue. “Executioner” kinds of these proteins cleave substrates such as actins and lamins to induce blebbing. (10[1])For 10 points, (10[1])name these proteases that operate in a cascading fashion during apoptosis ■END■ (0[2])

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Summary