Round 3: Tossup 13

An oxide of this element can be used alongside A·T·R·A to degrade P·M·L/R·A·R·A in sufferers of acute promyelocytic (“proh-MY-loh-SIH-tick”) leukemia. Another form of this element binds to the vicinal (“VISS-ih-null”) di·thiol of the lipoic acid cofactor of pyruvate dehydrogenase to inhibit the enzyme’s activity. Inorganic forms of this element are methylated into M·M·A and D·M·A in the liver. This element bonds to 2-amino·phenol to form an antimicrobial first used to kill off (*) Treponema pallidum. This is the heaviest element found in Salvarsan, (10[1])a drug developed by Paul Ehrlich’s lab (10[1])to treat syphilis. In its main mode of toxicity, this pnictogen’s oxyanion replaces phosphate during glycolysis to inhibit ATP synthesis. For 10 points, (10[1])name this toxic group 15 metalloid whose trioxide was once used as rat poison. ■END■ (10[1])

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