Packet 3: Tossup 13

An oxide of this element can be used alongside A·T·R·A to degrade P·M·L/R·A·R·A (15[1])in sufferers of acute (15[1])promyelocytic (“proh-MY-loh-SIH-tick”) leukemia. (15[1])Another form of this element binds to the vicinal (15[1])(“VISS-ih-null”) di·thiol of the lipoic acid cofactor of pyruvate dehydrogenase to inhibit the enzyme’s activity. (15[1])Inorganic forms of this element are methylated (15[1]-5[1])into M·M·A and D·M·A in the liver. This element bonds to 2-amino·phenol (15[1])to form an antimicrobial first used to kill off (*) Treponema pallidum. (10[1])This is the heaviest element found in (-5[1])Salvarsan, (10[1]-5[1])a drug developed (-5[1])by (10[1])Paul (10[1])Ehrlich’s (-5[1])lab (10[1])to treat syphilis. (-5[1])In its (-5[1])main mode of toxicity, this (10[1])pnictogen’s (10[1])oxyanion (-5[1])replaces (10[1])phosphate during glycolysis to inhibit ATP (10[2])synthesis. For 10 points, (10[1])name this toxic group (10[1])15 metalloid whose trioxide was once used as rat (10[1])poison. (10[1])■END■ (10[11]0[2])

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