Round 9: Tossup 21

The adaptor protein Hop binds to these proteins at domains ending with an E·E·V·D motif. One of these proteins assumes a “bullet” conformation over a “football” conformation when ADP binds to its trans-ring region. One of these proteins made up of Tim9 and Tim10 subunits assists in the translocation of “clients” across the mitochondrial intermembrane space. Prokaryotic examples of these proteins with a J-domain include DnaK and DnaJ. One of these proteins found in bacteria is paired with a heptameric (*) “lid” that can bind to either end of its GroEL barrel (10[1])to form a “nano-cage.” Most heat shock proteins, such as (10[1])Hsp70 and BiP, are also these kinds of proteins (10[1])that aid substrates in changing their tertiary structure. For 10 points, name these proteins that assist in the folding of polypeptides. ■END■ (10[1])

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Summary