Packet 10: Tossup 21

The adaptor protein Hop binds to these proteins at domains ending with an E·E·V·D motif. One of these proteins assumes a “bullet” conformation over a “football” conformation when ADP binds to its trans-ring region. One of these proteins made up of Tim9 and Tim10 subunits assists in the (15[1])translocation (-5[1])of “clients” across the mitochondrial (15[1])intermembrane space. Prokaryotic examples of these proteins with a J-domain include DnaK (15[1])and (-5[1])DnaJ. One of these proteins found (-5[1])in bacteria is paired with (10[1])a heptameric (*) “lid” (10[1])that can bind to either end (10[1])of its (-5[1])GroEL (10[2])barrel (10[1])to form a “nano-cage.” (10[2])Most heat shock proteins, (10[2])such as (10[1])Hsp70 (10[2])and BiP, (10[1])are also these kinds of proteins (10[1])that aid substrates (10[1])in changing their tertiary structure. For 10 points, (10[1])name these (10[1])proteins (10[1])that assist in the folding (10[1])of polypeptides. ■END■ (10[5])

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