Packet 10: Tossup 21
The adaptor protein Hop binds to these proteins at domains ending with an E·E·V·D motif. In S. cerevisiae, one of these proteins called zuotin crosslinks with N·A·Cs using its J-domain. One of these proteins assumes a “bullet” conformation over a “football” conformation when ADP binds to its trans-ring region. One of these proteins made up of Tim9 and Tim10 subunits assists in the translocation of “clients” across the mitochondrial intermembrane space. One of these proteins found in bacteria is paired with a heptameric (*) “lid” that can bind to either end of its GroEL portion to form a “nano-cage.” Most heat shock proteins, such as Hsp70 and BiP, are also these kinds of proteins that aid substrates in changing their tertiary structure. For 10 points, name these proteins that assist in the folding of polypeptides. ■END■
ANSWER: molecular chaperones [accept chaperonins; accept heat shock proteins until “heat shock” is read; accept foldases; accept holdases; prompt on Hsps or Hsp70 or BiP with “what kind of protein is it?” until “Hsp70” is read; prompt on GroEL with “what kind of protein is it?” until “GroEL” is read]
<KN, Biology> | NAFTA-Packet-10
= Average correct buzzpoint
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